Can Marijuana Use Prevent You From Giving Blood? Can you donate blood if you smoke? Can Cannabis Users Donate Blood Red Cross Are vape pens, or e cigarettes, ever the better option? Ohio State Health & Discovery Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post.